Betulinic Acid-Mediated Apoptosis in Human Prostate Cancer Cells Involves p53 and Nuclear Factor-Kappa B (NF-κB) Pathways

Betulinic Acid-Mediated Apoptosis in Human Prostate Cancer Cells Involves p53 and Nuclear Factor-Kappa B (NF-κB) Pathways

Defects in p53 and nuclear factor-kappa B (NF-κB) signaling pathways are frequently observed in the initiation and development of various human malignancies, including prostate cancer. Clinical studies demonstrate higher expression of NF-κB/p65/RelA, NF-κB/p50/RelB, and cRel as well as downregulatio...

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Bibliographic Details
Main Authors: Eswar Shankar, Ailin Zhang, Daniel Franco, Sanjay Gupta
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Molecules
Subjects:
prostate cancer
chemoprevention
apoptosis
betulinic acid
triterpenoid
Online Access:http://www.mdpi.com/1420-3049/22/2/264

Internet

http://www.mdpi.com/1420-3049/22/2/264

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