Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats

Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats

Hepatic mitochondrial function, APOC-III, and LPL are potential targets for triglyceride (TG)-lowering drugs. After 3 weeks of dietary treatment with the compound 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), the hepatic mitochondrial FA oxidation increased more than 5-fold in male Wistar rat...

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Bibliographic Details
Main Authors: Carine Lindquist, Bodil Bjørndal, Christine Renate Rossmann, Deusdedit Tusubira, Asbjørn Svardal, Gro Vatne Røsland, Karl Johan Tronstad, Seth Hallström, Rolf Kristian Berge
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Journal of Lipid Research
Subjects:
2-(tridec-12-yn-1-ylthio)acetic acid
lipids
lipoproteins
metabolic syndrome
mitochondria
nonalcoholic fatty liver disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335872

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http://www.sciencedirect.com/science/article/pii/S0022227520335872

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