Multiscale mathematical modeling in dental tissue engineering: towards computer-aided design of a regenerative system based on hydroxyapatite granules, focusing on early and mid-term stiffness recovery

We here explore for the very first time how an advanced multiscale mathematical modeling approach may support the design of a provenly successful tissue engineering concept for mandibular bone. The latter employs double-porous, potentially cracked, single millimeter-sized granules packed into an ove...

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Bibliographic Details
Main Authors: Stefan Scheiner, Vladimir S. Komlev, Alexey N. Gurin, Christian Hellmich
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00383/full