A molecular view on the escape of lipoplexed DNA from the endosome

A molecular view on the escape of lipoplexed DNA from the endosome

The use of non-viral vectors for in vivo gene therapy could drastically increase safety, whilst reducing the cost of preparing the vectors. A promising approach to non-viral vectors makes use of DNA/cationic liposome complexes (lipoplexes) to deliver the genetic material. Here we use coarse-grained...

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Bibliographic Details
Main Authors: Bart MH Bruininks, Paulo CT Souza, Helgi Ingolfsson, Siewert J Marrink
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
non-viral vector
transfection
lipoplex
molecular dynamics
martini
dotap
Online Access:https://elifesciences.org/articles/52012

Internet

https://elifesciences.org/articles/52012

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