A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity

A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity

The limited efficacy of seasonal influenza vaccines is usually attributed to ongoing variation in the major antigenic targets for protective antibody responses including hemagglutinin (HA) and neuraminidase (NA). Hence, vaccine development has largely focused on broadening antigenic epitopes to gene...

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Bibliographic Details
Main Authors: Fumi Sato-Kaneko, Shiyin Yao, Fitzgerald S. Lao, Jonathan Shpigelman, Karen Messer, Minya Pu, Nikunj M. Shukla, Howard B. Cottam, Michael Chan, Paul J. Chu, David Burkhart, Roman Schoener, Takaji Matsutani, Dennis A. Carson, Maripat Corr, Tomoko Hayashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
vaccine
combination adjuvant
synthetic TLR4 agonist
synthetic TLR7 agonists
small molecule
influenza virus infection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01207/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01207/full

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