A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity
The limited efficacy of seasonal influenza vaccines is usually attributed to ongoing variation in the major antigenic targets for protective antibody responses including hemagglutinin (HA) and neuraminidase (NA). Hence, vaccine development has largely focused on broadening antigenic epitopes to gene...
Main Authors: | Fumi Sato-Kaneko, Shiyin Yao, Fitzgerald S. Lao, Jonathan Shpigelman, Karen Messer, Minya Pu, Nikunj M. Shukla, Howard B. Cottam, Michael Chan, Paul J. Chu, David Burkhart, Roman Schoener, Takaji Matsutani, Dennis A. Carson, Maripat Corr, Tomoko Hayashi |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-06-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01207/full |
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