Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides

The application of nanofibres formed from monomers of bacterial type IV pili in vitrohas proven to be complex. Here, the authors have overcome this limitation by using a reductionist approach to design a self-assembling pilin-based 20-mer peptide capable of forming a supramolecular beta sheet.

Bibliographic Details
Main Authors: Tom Guterman, Micha Kornreich, Avigail Stern, Lihi Adler-Abramovich, Danny Porath, Roy Beck, Linda J. W. Shimon, Ehud Gazit
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13482