Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin

Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin

Whether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter.

Bibliographic Details
Main Authors: Pierrick Moreau, Axel Cournac, Gianna Aurora Palumbo, Martial Marbouty, Shogofa Mortaza, Agnes Thierry, Stefano Cairo, Marc Lavigne, Romain Koszul, Christine Neuveut
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06739-4

Internet

https://doi.org/10.1038/s41467-018-06739-4

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