Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin

Whether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter.

Bibliographic Details
Main Authors:	Pierrick Moreau, Axel Cournac, Gianna Aurora Palumbo, Martial Marbouty, Shogofa Mortaza, Agnes Thierry, Stefano Cairo, Marc Lavigne, Romain Koszul, Christine Neuveut
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06739-4

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spelling	doaj-878cd31675d7462e94de500ad56358132021-05-11T09:29:50ZengNature Publishing GroupNature Communications2041-17232018-10-019111410.1038/s41467-018-06739-4Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatinPierrick Moreau0Axel Cournac1Gianna Aurora Palumbo2Martial Marbouty3Shogofa Mortaza4Agnes Thierry5Stefano Cairo6Marc Lavigne7Romain Koszul8Christine Neuveut9Institut Pasteur, Unité Hepacivirus et Immunité InnéeInstitut Pasteur, Département Génomes et Génétique, Groupe Régulation spatiale des génomesInstitut Pasteur, Unité Hepacivirus et Immunité InnéeInstitut Pasteur, Département Génomes et Génétique, Groupe Régulation spatiale des génomesInstitut Pasteur, Département Génomes et Génétique, Groupe Régulation spatiale des génomesInstitut Pasteur, Département Génomes et Génétique, Groupe Régulation spatiale des génomesXenTech, Research and Development DepartmentInstitut Pasteur, Département de VirologieInstitut Pasteur, Département Génomes et Génétique, Groupe Régulation spatiale des génomesInstitut Pasteur, Unité Hepacivirus et Immunité InnéeWhether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter.https://doi.org/10.1038/s41467-018-06739-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pierrick Moreau Axel Cournac Gianna Aurora Palumbo Martial Marbouty Shogofa Mortaza Agnes Thierry Stefano Cairo Marc Lavigne Romain Koszul Christine Neuveut
spellingShingle	Pierrick Moreau Axel Cournac Gianna Aurora Palumbo Martial Marbouty Shogofa Mortaza Agnes Thierry Stefano Cairo Marc Lavigne Romain Koszul Christine Neuveut Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin Nature Communications
author_facet	Pierrick Moreau Axel Cournac Gianna Aurora Palumbo Martial Marbouty Shogofa Mortaza Agnes Thierry Stefano Cairo Marc Lavigne Romain Koszul Christine Neuveut
author_sort	Pierrick Moreau
title	Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
title_short	Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
title_full	Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
title_fullStr	Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
title_full_unstemmed	Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
title_sort	tridimensional infiltration of dna viruses into the host genome shows preferential contact with active chromatin
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-10-01
description	Whether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter.
url	https://doi.org/10.1038/s41467-018-06739-4
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Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin

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