Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin
Whether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter.
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2018-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-06739-4 |
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doaj-878cd31675d7462e94de500ad56358132021-05-11T09:29:50ZengNature Publishing GroupNature Communications2041-17232018-10-019111410.1038/s41467-018-06739-4Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatinPierrick Moreau0Axel Cournac1Gianna Aurora Palumbo2Martial Marbouty3Shogofa Mortaza4Agnes Thierry5Stefano Cairo6Marc Lavigne7Romain Koszul8Christine Neuveut9Institut Pasteur, Unité Hepacivirus et Immunité InnéeInstitut Pasteur, Département Génomes et Génétique, Groupe Régulation spatiale des génomesInstitut Pasteur, Unité Hepacivirus et Immunité InnéeInstitut Pasteur, Département Génomes et Génétique, Groupe Régulation spatiale des génomesInstitut Pasteur, Département Génomes et Génétique, Groupe Régulation spatiale des génomesInstitut Pasteur, Département Génomes et Génétique, Groupe Régulation spatiale des génomesXenTech, Research and Development DepartmentInstitut Pasteur, Département de VirologieInstitut Pasteur, Département Génomes et Génétique, Groupe Régulation spatiale des génomesInstitut Pasteur, Unité Hepacivirus et Immunité InnéeWhether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter.https://doi.org/10.1038/s41467-018-06739-4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pierrick Moreau Axel Cournac Gianna Aurora Palumbo Martial Marbouty Shogofa Mortaza Agnes Thierry Stefano Cairo Marc Lavigne Romain Koszul Christine Neuveut |
spellingShingle |
Pierrick Moreau Axel Cournac Gianna Aurora Palumbo Martial Marbouty Shogofa Mortaza Agnes Thierry Stefano Cairo Marc Lavigne Romain Koszul Christine Neuveut Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin Nature Communications |
author_facet |
Pierrick Moreau Axel Cournac Gianna Aurora Palumbo Martial Marbouty Shogofa Mortaza Agnes Thierry Stefano Cairo Marc Lavigne Romain Koszul Christine Neuveut |
author_sort |
Pierrick Moreau |
title |
Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin |
title_short |
Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin |
title_full |
Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin |
title_fullStr |
Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin |
title_full_unstemmed |
Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin |
title_sort |
tridimensional infiltration of dna viruses into the host genome shows preferential contact with active chromatin |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-10-01 |
description |
Whether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter. |
url |
https://doi.org/10.1038/s41467-018-06739-4 |
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