The Unfolded Protein Response Is a Major Driver of LCN2 Expression in BCR–ABL- and JAK2V617F-Positive MPN

The Unfolded Protein Response Is a Major Driver of LCN2 Expression in BCR–ABL- and JAK2V617F-Positive MPN

Lipocalin 2 (LCN2), a proinflammatory mediator, is involved in the pathogenesis of myeloproliferative neoplasms (MPN). Here, we investigated the molecular mechanisms of LCN2 overexpression in MPN. LCN2 mRNA expression was 20-fold upregulated in peripheral blood (PB) mononuclear cells of chronic myel...

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Bibliographic Details
Main Authors: Stefan Tillmann, Kathrin Olschok, Sarah K. Schröder, Marlena Bütow, Julian Baumeister, Milena Kalmer, Vera Preußger, Barbora Weinbergerova, Kim Kricheldorf, Jiri Mayer, Blanka Kubesova, Zdenek Racil, Martina Wessiepe, Jörg Eschweiler, Susanne Isfort, Tim H. Brümmendorf, Walter Becker, Mirle Schemionek, Ralf Weiskirchen, Steffen Koschmieder, Nicolas Chatain
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
Lipocalin 2 (LCN2)
NGAL
ER stress
UPR
MPN
BCR-ABL
Online Access:https://www.mdpi.com/2072-6694/13/16/4210

Internet

https://www.mdpi.com/2072-6694/13/16/4210

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