In search of selective 11β-HSD type 1 inhibitors without nephrotoxicity: An approach to resolve the metabolic syndrome by virtual based screening

In search of selective 11β-HSD type 1 inhibitors without nephrotoxicity: An approach to resolve the metabolic syndrome by virtual based screening

Over expression of 11β-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11β-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of grea...

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Bibliographic Details
Main Authors: Harun Patel, Kiran Dhangar, Yogesh Sonawane, Sanjay Surana, Rajshekhar Karpoormath, Neeta Thapliyal, Mahamadhanif Shaikh, Malleshappa Noolvi, Rakesh Jagtap
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Arabian Journal of Chemistry
Subjects:
11β-HSD 1
Virtual screening
PASS toxicity
Lipinski’s rule
ADME
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535215002439

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http://www.sciencedirect.com/science/article/pii/S1878535215002439

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