Deep-sequencing of Marburg virus genome during sequential mouse passaging and cell-culture adaptation reveals extensive changes over time

Deep-sequencing of Marburg virus genome during sequential mouse passaging and cell-culture adaptation reveals extensive changes over time

Abstract Marburg virus (MARV) has caused outbreaks of filoviral hemorrhagic fever since its discovery in 1967. The largest and deadliest outbreak occurred in Angola in 2005, with 252 cases and 227 deaths. In 2014, we developed a mouse-adapted MARV, Angola variant through serial passaging in mice. Th...

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Bibliographic Details
Main Authors: Haiyan Wei, Jonathan Audet, Gary Wong, Shihua He, Xueyong Huang, Todd Cutts, Steven Theriault, Bianli Xu, Gary Kobinger, Xiangguo Qiu
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03318-3

Internet

https://doi.org/10.1038/s41598-017-03318-3

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