Strong Ligand-Protein Interactions Derived from Diffuse Ligand Interactions with Loose Binding Sites
Many systems in biology rely on binding of ligands to target proteins in a single high-affinity conformation with a favorable ΔG. Alternatively, interactions of ligands with protein regions that allow diffuse binding, distributed over multiple sites and conformations, can exhibit favorable ΔG becaus...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2015-01-01
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| Series: | BioMed Research International |
| Online Access: | http://dx.doi.org/10.1155/2015/746980 |