Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy

Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy

Intracellular deposition of hyperphosphorylated tau has been reported in the brain of epilepsy patients, but its contribution to epileptic seizures and the association with spatial cognitive functions remain unclear. Here, we found that repeated optogenetic stimulation of the excitatory neurons in v...

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Bibliographic Details
Main Authors: Yang Gao, Jie Zheng, Tao Jiang, Guilin Pi, Fei Sun, Rui Xiong, Weijin Wang, Dongqin Wu, Shihong Li, Huiyang Lei, Huiling Yu, Qiuzhi Zhou, Ying Yang, Huaqiu Zhang, Jian-Zhi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
epilepsy
cognitive impairment
tau hyperphosphorylation
optogenetics
mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.633725/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.633725/full

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