Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles

Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles

Summary: Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore organ function is not fully understood. Here, we show that a substanti...

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Bibliographic Details
Main Authors: Krishnamoorthy Sreenivasan, Alessandro Ianni, Carsten Künne, Boris Strilic, Stefan Günther, Eusebio Perdiguero, Marcus Krüger, Simone Spuler, Stefan Offermanns, Pablo Gómez-del Arco, Juan Miguel Redondo, Pura Munoz-Canoves, Johnny Kim, Thomas Braun
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
muscle stem cells
regeneration
necroptosis
muscle dystrophy
Chd4/NuRD
Ripk3
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306057

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http://www.sciencedirect.com/science/article/pii/S2211124720306057

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