Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions

Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions

Recent studies have suggested that human pluripotent stem cells (hPSCs) depend primarily on glycolysis and only increase oxidative metabolism during differentiation. Here, we demonstrate that both glycolytic and oxidative metabolism can support hPSC growth and that the metabolic phenotype of hPSCs i...

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Bibliographic Details
Main Authors: Hui Zhang, Mehmet G. Badur, Ajit S. Divakaruni, Seth J. Parker, Christian Jäger, Karsten Hiller, Anne N. Murphy, Christian M. Metallo
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308713

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http://www.sciencedirect.com/science/article/pii/S2211124716308713

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