Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism

Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism

Objective: Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein kinase (AMPK) associates with glycogen via its regulatory β subunit carbohydrate-binding module (CBM). However, the physiological role of AMPK-glycogen binding in energy h...

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Bibliographic Details
Main Authors: Nolan J. Hoffman, Jamie Whitfield, Natalie R. Janzen, Mehdi R. Belhaj, Sandra Galic, Lisa Murray-Segal, William J. Smiles, Naomi X.Y. Ling, Toby A. Dite, John W. Scott, Jonathan S. Oakhill, Robert Brink, Bruce E. Kemp, John A. Hawley
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Molecular Metabolism
Subjects:
AMP-activated protein kinase
Carbohydrate-binding module
Cellular energy sensing
Exercise
Liver
Skeletal muscle
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301228

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http://www.sciencedirect.com/science/article/pii/S2212877820301228

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