Therapeutic Efficacy of a Novel Acetylated Tetrapeptide in Animal Models of Age-Related Macular Degeneration

Therapeutic Efficacy of a Novel Acetylated Tetrapeptide in Animal Models of Age-Related Macular Degeneration

It has been shown previously that a novel tetrapeptide, Arg-Leu-Tyr-Glu (RLYE), derived from human plasminogen inhibits vascular endothelial growth factor (VEGF)-induced angiogenesis, suppresses choroidal neovascularization in mice by an inhibition of VEGF receptor-2 (VEGFR-2) specific signaling pat...

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Bibliographic Details
Main Authors: Hye Cheong Koo, Yi-Yong Baek, Jun-Sup Choi, Young-Myeong Kim, Bokyung Sung, Min-Jung Kim, Jae Gyu Kim, Ji Chang You
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
acetylated tetrapeptide (Ac-RLYE)
neovascular age-related macular degeneration
resistance
retinal neovascularization
laser-induced CNV model
VEGF
Online Access:https://www.mdpi.com/1422-0067/22/8/3893

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https://www.mdpi.com/1422-0067/22/8/3893

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