Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

Abstract Background Subarachnoid hemorrhage (SAH) is a life-threatening subtype of stroke with high mortality and disabilities. Retinoid X receptor (RXR) has been shown to be neuroprotective against ischemia/reperfusion injury. This study aimed to investigate the effects of the selective RXR agonist...

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Bibliographic Details
Main Authors: Yuchun Zuo, Lei Huang, Budbazar Enkhjargal, Weilin Xu, Ocak Umut, Zachary D. Travis, Guangyu Zhang, Jiping Tang, Fei Liu, John H. Zhang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Neuroinflammation
Subjects:
Subarachnoid hemorrhage
Retinoid X receptor
Bexarotene
Sirtuin 6
Neuroinflammation
Brain edema
Online Access:http://link.springer.com/article/10.1186/s12974-019-1432-5

Internet

http://link.springer.com/article/10.1186/s12974-019-1432-5

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