Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload.

Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload.

Connective tissue growth factor (CTGF) is a secreted protein that is strongly induced in human and experimental heart failure. CTGF is said to be profibrotic; however, the precise function of CTGF is unclear. We generated transgenic mice and rats with cardiomyocyte-specific CTGF overexpression (CTGF...

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Bibliographic Details
Main Authors: Anna N Panek, Maximilian G Posch, Natalia Alenina, Santhosh K Ghadge, Bettina Erdmann, Elena Popova, Andreas Perrot, Christian Geier, Rainer Dietz, Ingo Morano, Michael Bader, Cemil Ozcelik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2727794?pdf=render

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http://europepmc.org/articles/PMC2727794?pdf=render

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