Monitoring of Early Changes of Circulating Tumor DNA in the Plasma of Rectal Cancer Patients Receiving Neoadjuvant Concomitant Chemoradiotherapy: Evaluation for Prognosis and Prediction of Therapeutic Response

Monitoring of Early Changes of Circulating Tumor DNA in the Plasma of Rectal Cancer Patients Receiving Neoadjuvant Concomitant Chemoradiotherapy: Evaluation for Prognosis and Prediction of Therapeutic Response

Introduction: Patients with locally advanced rectal cancer (LARC) are undergoing neoadjuvant chemoradiotherapy (NCRT) prior to surgery. Although in some patients the NCRT is known to prevent local recurrence, it is also accompanied by side effects. Accordingly, there is an unmet need to identify pre...

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Bibliographic Details
Main Authors: Filip Pazdirek, Marek Minarik, Lucie Benesova, Tereza Halkova, Barbora Belsanova, Milan Macek, Lubomír Stepanek, Jiri Hoch
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
rectal cancer
neoadjuvant chemoradiotherapy
circulating tumor ctDNA
prediction
prognosis
response
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01028/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01028/full

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