Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein

Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein

Genistein, a potent antioxidant compound, protects dopaminergic neurons in a mouse model of Parkinson's disease. However, the mechanism underlying this action remains unknown. This study investigated human SH-SY5Y cells overexpressing the A53T mutant of α-synuclein. Four groups of cells were as...

Full description

Bibliographic Details
Main Authors: Huan-Cheng Wu, Qun-Liang Hu, Shi-Jun Zhang, Yan-Min Wang, Zhan-Kui Jin, Ling-Fu Lv, Sai Zhang, Zhen-Lin Liu, Hong-Lian Wu, Ou-Mei Cheng
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; genistein; neuroprotection; SH-SY5Y cells; Parkinson′s disease; rotenone; estrogen receptor; NFE2L2; A53T; α-synuclein; oxidative stress; neurodegeneration; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=8;spage=1375;epage=1383;aulast=Wu

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=8;spage=1375;epage=1383;aulast=Wu

Similar Items