Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells.

Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells.

Alcohol intoxication results in neuronal apoptosis, neurodegeneration and manifest with impaired balance, loss of muscle coordination and behavioral changes. One of the early events of alcohol intoxication is mitochondrial (Mt) dysfunction and disruption of intracellular redox homeostasis. The mecha...

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Bibliographic Details
Main Authors: Zilong Liu, Yongping Liu, Rui Gao, Haixia Li, Tiffany Dunn, Ping Wu, Robert G Smith, Partha S Sarkar, Xiang Fang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4123904?pdf=render

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http://europepmc.org/articles/PMC4123904?pdf=render

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