The sheddase ADAM10 is a potent modulator of prion disease

The sheddase ADAM10 is a potent modulator of prion disease

The prion protein (PrPC) is highly expressed in the nervous system and critically involved in prion diseases where it misfolds into pathogenic PrPSc. Moreover, it has been suggested as a receptor mediating neurotoxicity in common neurodegenerative proteinopathies such as Alzheimer's disease. Pr...

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Bibliographic Details
Main Authors: Hermann C Altmeppen, Johannes Prox, Susanne Krasemann, Berta Puig, Katharina Kruszewski, Frank Dohler, Christian Bernreuther, Ana Hoxha, Luise Linsenmeier, Beata Sikorska, Pawel P Liberski, Udo Bartsch, Paul Saftig, Markus Glatzel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-02-01
Series:eLife
Subjects:
ADAM10
neurodegeneration
prion disease
proteolytic processing
shedding
Online Access:https://elifesciences.org/articles/04260

Internet

https://elifesciences.org/articles/04260

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