Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review
Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin. This neoplasia features aggressive behavior, resulting in a 5-year overall survival rate of 40%. In 2008, Feng et al. identified Merkel cell polyomavirus (MCPyV) integration into the host genome as the main event leading...
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doaj-87cd8456e5ac4dc8901879c3056672be2020-11-25T00:16:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-06-01910.3389/fonc.2019.00451441609Histogenesis of Merkel Cell Carcinoma: A Comprehensive ReviewThibault Kervarrec0Thibault Kervarrec1Thibault Kervarrec2Mahtab Samimi3Mahtab Samimi4Serge Guyétant5Serge Guyétant6Bhavishya Sarma7Jérémy Chéret8Emmanuelle Blanchard9Emmanuelle Blanchard10Patricia Berthon11David Schrama12Roland Houben13Antoine Touzé14Department of Pathology, Centre Hospitalier Universitaire de Tours, Tours, FranceISP “Biologie des infections à polyomavirus” team, UMR INRA 1282, University of Tours, Tours, FranceDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, GermanyISP “Biologie des infections à polyomavirus” team, UMR INRA 1282, University of Tours, Tours, FranceDepartement of Dermatology, Centre Hospitalier Universitaire de Tours, Tours, FranceDepartment of Pathology, Centre Hospitalier Universitaire de Tours, Tours, FranceISP “Biologie des infections à polyomavirus” team, UMR INRA 1282, University of Tours, Tours, FranceDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, GermanyMonasterium Laboratory, Skin and Hair Research Solutions GmbH, Münster, GermanyDepartment of Pathology, Centre Hospitalier Universitaire de Tours, Tours, FrancePlateforme IBiSA de Microscopie Electronique, INSERM 1259, Université de Tours, Tours, FranceISP “Biologie des infections à polyomavirus” team, UMR INRA 1282, University of Tours, Tours, FranceDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, GermanyDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, GermanyISP “Biologie des infections à polyomavirus” team, UMR INRA 1282, University of Tours, Tours, FranceMerkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin. This neoplasia features aggressive behavior, resulting in a 5-year overall survival rate of 40%. In 2008, Feng et al. identified Merkel cell polyomavirus (MCPyV) integration into the host genome as the main event leading to MCC oncogenesis. However, despite identification of this crucial viral oncogenic trigger, the nature of the cell in which MCC oncogenesis occurs is actually unknown. In fact, several hypotheses have been proposed. Despite the large similarity in phenotype features between MCC tumor cells and physiological Merkel cells (MCs), a specialized subpopulation of the epidermis acting as mechanoreceptor of the skin, several points argue against the hypothesis that MCC derives directly from MCs. Alternatively, MCPyV integration could occur in another cell type and induce acquisition of an MC-like phenotype. Accordingly, an epithelial as well as a fibroblastic or B-cell origin of MCC has been proposed mainly based on phenotype similarities shared by MCC and these potential ancestries. The aim of this present review is to provide a comprehensive review of the current knowledge of the histogenesis of MCC.https://www.frontiersin.org/article/10.3389/fonc.2019.00451/fullmerkel cell polyomavirus (MCPyV)epithelialfibroblastB cellMerkel cell carcinoma (MCC)histogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thibault Kervarrec Thibault Kervarrec Thibault Kervarrec Mahtab Samimi Mahtab Samimi Serge Guyétant Serge Guyétant Bhavishya Sarma Jérémy Chéret Emmanuelle Blanchard Emmanuelle Blanchard Patricia Berthon David Schrama Roland Houben Antoine Touzé |
spellingShingle |
Thibault Kervarrec Thibault Kervarrec Thibault Kervarrec Mahtab Samimi Mahtab Samimi Serge Guyétant Serge Guyétant Bhavishya Sarma Jérémy Chéret Emmanuelle Blanchard Emmanuelle Blanchard Patricia Berthon David Schrama Roland Houben Antoine Touzé Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review Frontiers in Oncology merkel cell polyomavirus (MCPyV) epithelial fibroblast B cell Merkel cell carcinoma (MCC) histogenesis |
author_facet |
Thibault Kervarrec Thibault Kervarrec Thibault Kervarrec Mahtab Samimi Mahtab Samimi Serge Guyétant Serge Guyétant Bhavishya Sarma Jérémy Chéret Emmanuelle Blanchard Emmanuelle Blanchard Patricia Berthon David Schrama Roland Houben Antoine Touzé |
author_sort |
Thibault Kervarrec |
title |
Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review |
title_short |
Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review |
title_full |
Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review |
title_fullStr |
Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review |
title_full_unstemmed |
Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review |
title_sort |
histogenesis of merkel cell carcinoma: a comprehensive review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2019-06-01 |
description |
Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin. This neoplasia features aggressive behavior, resulting in a 5-year overall survival rate of 40%. In 2008, Feng et al. identified Merkel cell polyomavirus (MCPyV) integration into the host genome as the main event leading to MCC oncogenesis. However, despite identification of this crucial viral oncogenic trigger, the nature of the cell in which MCC oncogenesis occurs is actually unknown. In fact, several hypotheses have been proposed. Despite the large similarity in phenotype features between MCC tumor cells and physiological Merkel cells (MCs), a specialized subpopulation of the epidermis acting as mechanoreceptor of the skin, several points argue against the hypothesis that MCC derives directly from MCs. Alternatively, MCPyV integration could occur in another cell type and induce acquisition of an MC-like phenotype. Accordingly, an epithelial as well as a fibroblastic or B-cell origin of MCC has been proposed mainly based on phenotype similarities shared by MCC and these potential ancestries. The aim of this present review is to provide a comprehensive review of the current knowledge of the histogenesis of MCC. |
topic |
merkel cell polyomavirus (MCPyV) epithelial fibroblast B cell Merkel cell carcinoma (MCC) histogenesis |
url |
https://www.frontiersin.org/article/10.3389/fonc.2019.00451/full |
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