Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na<sub>V</sub> Channel Inhibitor

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na<sub>V</sub> Channel Inhibitor

Voltage-gated sodium (Na<sub>V</sub>) channel subtypes, including Na<sub>V</sub>1.7, are promising targets for the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ-conotoxins are small, potent Na<sub>V</sub> channel inhibitors which r...

Full description

Bibliographic Details
Main Authors: Kirsten L. McMahon, Hue N.T. Tran, Jennifer R. Deuis, Richard J. Lewis, Irina Vetter, Christina I. Schroeder
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Biomedicines
Subjects:
chronic pain
µ-conotoxin
Na<sub>V</sub> channels
pore blocker
whole-cell patch-clamp electrophysiology
NMR
Online Access:https://www.mdpi.com/2227-9059/8/10/391

Internet

https://www.mdpi.com/2227-9059/8/10/391

Similar Items