Role of PLEXIND1/TGFβ Signaling Axis in Pancreatic Ductal Adenocarcinoma Progression Correlates with the Mutational Status of <i>KRAS</i>

Role of PLEXIND1/TGFβ Signaling Axis in Pancreatic Ductal Adenocarcinoma Progression Correlates with the Mutational Status of <i>KRAS</i>

PLEXIND1 is upregulated in several cancers, including pancreatic ductal adenocarcinoma (PDAC). It is an established mediator of semaphorin signaling, and neuropilins are its known coreceptors. Herein, we report data to support the proposal that PLEXIND1 acts as a transforming growth factor beta (TGF...

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Bibliographic Details
Main Authors: Sneha Vivekanandhan, Vijay S. Madamsetty, Ramcharan Singh Angom, Shamit Kumar Dutta, Enfeng Wang, Thomas Caulfield, Alexandre A. Pletnev, Rosanna Upstill-Goddard, Yan W. Asmann, David Chang, Mark R. Spaller, Debabrata Mukhopadhyay
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
PLEXIND1
KRAS
TGFβ
SMAD
Online Access:https://www.mdpi.com/2072-6694/13/16/4048

Internet

https://www.mdpi.com/2072-6694/13/16/4048

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