Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion

Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion

Mutations in subunits of succinyl-CoA synthetase/ligase (SCS), a component of the citric acid cycle, are associated with mitochondrial encephalomyopathy, elevation of methylmalonic acid (MMA), and mitochondrial DNA (mtDNA) depletion. A FACS-based retroviral-mediated gene trap mutagenesis screen in m...

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Bibliographic Details
Main Authors: Taraka R. Donti, Carmen Stromberger, Ming Ge, Karen W. Eldin, William J. Craigen, Brett H. Graham
Format: Article
Language:English
Published: The Company of Biologists 2014-02-01
Series:Disease Models & Mechanisms
Subjects:
TCA cycle
Mitochondrial DNA depletion
Gene trap
Mitochondria
Online Access:http://dmm.biologists.org/content/7/2/271

Internet

http://dmm.biologists.org/content/7/2/271

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