Epigenetic prediction of complex traits and death

Epigenetic prediction of complex traits and death

Abstract Background Genome-wide DNA methylation (DNAm) profiling has allowed for the development of molecular predictors for a multitude of traits and diseases. Such predictors may be more accurate than the self-reported phenotypes and could have clinical applications. Results Here, penalized regres...

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Bibliographic Details
Main Authors: Daniel L. McCartney, Robert F. Hillary, Anna J. Stevenson, Stuart J. Ritchie, Rosie M. Walker, Qian Zhang, Stewart W. Morris, Mairead L. Bermingham, Archie Campbell, Alison D. Murray, Heather C. Whalley, Catharine R. Gale, David J. Porteous, Chris S. Haley, Allan F. McRae, Naomi R. Wray, Peter M. Visscher, Andrew M. McIntosh, Kathryn L. Evans, Ian J. Deary, Riccardo E. Marioni
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Genome Biology
Subjects:
DNA methylation
Polygenic scores
Prediction
Ageing
Mortality
Online Access:http://link.springer.com/article/10.1186/s13059-018-1514-1

Internet

http://link.springer.com/article/10.1186/s13059-018-1514-1

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