Overview of Ferroptosis and Synthetic Lethality Strategies

Overview of Ferroptosis and Synthetic Lethality Strategies

Ferroptosis, a term first proposed in 2012, is iron-dependent, non-apoptotic regulatory cell death induced by erastin. Ferroptosis was originally discovered during synthetic lethal screening for drugs sensitive to RAS mutant cells, and is closely related to synthetic lethality. Ferroptosis sensitize...

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Bibliographic Details
Main Authors: Yuko Kinowaki, Towako Taguchi, Iichiroh Onishi, Susumu Kirimura, Masanobu Kitagawa, Kouhei Yamamoto
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
ferroptosis
synthetic lethality
CRISPR-Cas9 screen
GPX4
FSP1
Online Access:https://www.mdpi.com/1422-0067/22/17/9271

Internet

https://www.mdpi.com/1422-0067/22/17/9271

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