Simple adjustment of the sequence weight algorithm remarkably enhances PSI-BLAST performance

Simple adjustment of the sequence weight algorithm remarkably enhances PSI-BLAST performance

Abstract Background PSI-BLAST, an extremely popular tool for sequence similarity search, features the utilization of Position-Specific Scoring Matrix (PSSM) constructed from a multiple sequence alignment (MSA). PSSM allows the detection of more distant homologs than a general amino acid substitution...

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Bibliographic Details
Main Authors: Toshiyuki Oda, Kyungtaek Lim, Kentaro Tomii
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Bioinformatics
Subjects:
PSI-BLAST
Sequence similarity search
Sequence weighting
Position-specific scoring matrix
Online Access:http://link.springer.com/article/10.1186/s12859-017-1686-9

Internet

http://link.springer.com/article/10.1186/s12859-017-1686-9

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