Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase

<p>Abstract</p> <p>Background</p> <p>Alzheimer’s disease (AD) is a neurologically degenerative disorder that affects more than 20 million people worldwide. The selective butyrylcholinesterase (BChE) inhibitors and bivalent cholinesterase (ChE) inhibitors represent new t...

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Bibliographic Details
Main Authors: Wang Yue-Hu, Wan Qin-Li, Gu Cheng-Ding, Luo Huai-Rong, Long Chun-Lin
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Chemistry Central Journal
Subjects:
Online Access:http://journal.chemistrycentral.com/content/6/1/96