Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a

The mechanisms of formation of the distinct sensory organs of the inner ear and the non-sensory domains that separate them are still unclear. Here, we show that several sensory patches arise by progressive segregation from a common prosensory domain in the embryonic chicken and mouse otocyst. This p...

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Bibliographic Details
Main Authors: Zoe F Mann, Héctor Gálvez, David Pedreno, Ziqi Chen, Elena Chrysostomou, Magdalena Żak, Miso Kang, Elachumee Canden, Nicolas Daudet
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/33323