Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma

Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma

Th2 cells are critical in the resolution of helminth infection and allergy. Here the authors show that Bcl11b is required to license the Th2 program of helper T cell differentiation and restrict alternate lineage gene expression using in vivo models of helminth infection and asthma.

Bibliographic Details
Main Authors: Kyle J. Lorentsen, Jonathan J. Cho, Xiaoping Luo, Ashley N. Zuniga, Joseph F. Urban, Liang Zhou, Raad Gharaibeh, Christian Jobin, Michael P. Kladde, Dorina Avram
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04111-0

Internet

https://doi.org/10.1038/s41467-018-04111-0

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