Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway

Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway

Intestinal epithelial cells (IECs) act as sentinels for incoming pathogens. Cytosol-invasive bacteria, such as Shigella flexneri, trigger a robust pro-inflammatory nuclear factor κB (NF-κB) response from IECs that is believed to depend entirely on the peptidoglycan sensor NOD1. We found that, during...

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Bibliographic Details
Main Authors: Ryan G. Gaudet, Cynthia X. Guo, Raphael Molinaro, Haila Kottwitz, John R. Rohde, Anne-Sophie Dangeard, Cécile Arrieumerlou, Stephen E. Girardin, Scott D. Gray-Owen
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
innate immunity
intracellular bacteria
inflammation
pattern recognition
Shigella
heptose
TIFA
NOD-like receptors
PAMP
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717305740

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http://www.sciencedirect.com/science/article/pii/S2211124717305740

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