Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
Nasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a pharmacogenomics strategy integrating genomics and dru...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23379-3 |
| id |
doaj-87f829886bef4facb841e43c9c543db3 |
|---|---|
| record_format |
Article |
| spelling |
doaj-87f829886bef4facb841e43c9c543db32021-05-30T11:13:17ZengNature Publishing GroupNature Communications2041-17232021-05-0112111910.1038/s41467-021-23379-3Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomicsRen-Bo Ding0Ping Chen1Barani Kumar Rajendran2Xueying Lyu3Haitao Wang4Jiaolin Bao5Jianming Zeng6Wenhui Hao7Heng Sun8Ada Hang-Heng Wong9Monica Vishnu Valecha10Eun Ju Yang11Sek Man Su12Tak Kan Choi13Shuiming Liu14Kin Iong Chan15Ling-Lin Yang16Jingbo Wu17Kai Miao18Qiang Chen19Joong Sup Shim20Xiaoling Xu21Chu-Xia Deng22Cancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauKiang Wu HospitalKiang Wu HospitalDepartment of Oncology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, The Affiliated Hospital of Southwest Medical UniversityCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauNasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a pharmacogenomics strategy integrating genomics and drug response of patient-derived organoids.https://doi.org/10.1038/s41467-021-23379-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ren-Bo Ding Ping Chen Barani Kumar Rajendran Xueying Lyu Haitao Wang Jiaolin Bao Jianming Zeng Wenhui Hao Heng Sun Ada Hang-Heng Wong Monica Vishnu Valecha Eun Ju Yang Sek Man Su Tak Kan Choi Shuiming Liu Kin Iong Chan Ling-Lin Yang Jingbo Wu Kai Miao Qiang Chen Joong Sup Shim Xiaoling Xu Chu-Xia Deng |
| spellingShingle |
Ren-Bo Ding Ping Chen Barani Kumar Rajendran Xueying Lyu Haitao Wang Jiaolin Bao Jianming Zeng Wenhui Hao Heng Sun Ada Hang-Heng Wong Monica Vishnu Valecha Eun Ju Yang Sek Man Su Tak Kan Choi Shuiming Liu Kin Iong Chan Ling-Lin Yang Jingbo Wu Kai Miao Qiang Chen Joong Sup Shim Xiaoling Xu Chu-Xia Deng Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics Nature Communications |
| author_facet |
Ren-Bo Ding Ping Chen Barani Kumar Rajendran Xueying Lyu Haitao Wang Jiaolin Bao Jianming Zeng Wenhui Hao Heng Sun Ada Hang-Heng Wong Monica Vishnu Valecha Eun Ju Yang Sek Man Su Tak Kan Choi Shuiming Liu Kin Iong Chan Ling-Lin Yang Jingbo Wu Kai Miao Qiang Chen Joong Sup Shim Xiaoling Xu Chu-Xia Deng |
| author_sort |
Ren-Bo Ding |
| title |
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics |
| title_short |
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics |
| title_full |
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics |
| title_fullStr |
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics |
| title_full_unstemmed |
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics |
| title_sort |
molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-05-01 |
| description |
Nasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a pharmacogenomics strategy integrating genomics and drug response of patient-derived organoids. |
| url |
https://doi.org/10.1038/s41467-021-23379-3 |
| work_keys_str_mv |
AT renboding molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT pingchen molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT baranikumarrajendran molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT xueyinglyu molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT haitaowang molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT jiaolinbao molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT jianmingzeng molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT wenhuihao molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT hengsun molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT adahanghengwong molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT monicavishnuvalecha molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT eunjuyang molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT sekmansu molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT takkanchoi molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT shuimingliu molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT kiniongchan molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT linglinyang molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT jingbowu molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT kaimiao molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT qiangchen molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT joongsupshim molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT xiaolingxu molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics AT chuxiadeng molecularlandscapeandsubtypespecifictherapeuticresponseofnasopharyngealcarcinomarevealedbyintegrativepharmacogenomics |
| _version_ |
1721420611295641600 |