A primary nasopharyngeal three-dimensional air-liquid interface cell culture model of the pseudostratified epithelium reveals differential donor- and cell type-specific susceptibility to Epstein-Barr virus infection.

A primary nasopharyngeal three-dimensional air-liquid interface cell culture model of the pseudostratified epithelium reveals differential donor- and cell type-specific susceptibility to Epstein-Barr virus infection.

Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus with latent and lytic cycles. EBV replicates in the stratified epithelium but the nasopharynx is also composed of pseudostratified epithelium with distinct cell types. Latent infection is associated with nasopharyngeal carcinoma (NPC). Here, we...

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Bibliographic Details
Main Authors: Phillip Ziegler, Yarong Tian, Yulong Bai, Sanna Abrahamsson, Alan Bäckerholm, Alex S Reznik, Anthony Green, John A Moore, Stella E Lee, Michael M Myerburg, Hyun Jung Park, Ka-Wei Tang, Kathy Ho Yen Shair
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009041

Internet

https://doi.org/10.1371/journal.ppat.1009041

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