Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells

Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells

Enveloped viruses hijack not only the host translation processes, but also its glycosylation machinery, and to a variable extent cover viral surface proteins with tolerogenic host-like structures. SARS-CoV-2 surface protein S presents as a trimer on the viral surface and is covered by a dense shield...

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Bibliographic Details
Main Authors: Ieva Bagdonaite, Andrew J. Thompson, Xiaoning Wang, Max Søgaard, Cyrielle Fougeroux, Martin Frank, Jolene K. Diedrich, John R. Yates III, Ali Salanti, Sergey Y. Vakhrushev, James C. Paulson, Hans H. Wandall
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Viruses
Subjects:
SARS-CoV-2
O-glycoproteomics
site-specific glycosylation
molecular modelling
COVID-19
GalNAc
Online Access:https://www.mdpi.com/1999-4915/13/4/551

Internet

https://www.mdpi.com/1999-4915/13/4/551

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