An ER translocon for multi-pass membrane protein biogenesis

An ER translocon for multi-pass membrane protein biogenesis

Membrane proteins with multiple transmembrane domains play critical roles in cell physiology, but little is known about the machinery coordinating their biogenesis at the endoplasmic reticulum. Here we describe a ~ 360 kDa ribosome-associated complex comprising the core Sec61 channel and five access...

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Bibliographic Details
Main Authors: Philip T McGilvray, S Andrei Anghel, Arunkumar Sundaram, Frank Zhong, Michael J Trnka, James R Fuller, Hong Hu, Alma L Burlingame, Robert J Keenan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
translocon
co-translational
human disease
endoplasmic reticulum
multi-pass membrane protein
folding
Online Access:https://elifesciences.org/articles/56889

Internet

https://elifesciences.org/articles/56889

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