IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice

IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice

The metabolic gene isocitrate dehydrogenase 1 (IDH1) is commonly mutated in lower grade glioma (LGG) and secondary glioblastoma (GBM). Regulatory T cells (Tregs) play a significant role in the suppression of antitumor immunity in human glioma. Given the importance of Tregs in the overall framework o...

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Bibliographic Details
Main Authors: Leland G. Richardson, Linda T. Nieman, Anat O. Stemmer-Rachamimov, Xijin S. Zheng, Khalifa Stafford, Hiroaki Nagashima, Julie J. Miller, Juri Kiyokawa, David T. Ting, Hiroaki Wakimoto, Daniel P. Cahill, Bryan D. Choi, William T. Curry
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
regulatory t cells
idh-mutation
glioma
immune microenvironment
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1806662

Internet

http://dx.doi.org/10.1080/2162402X.2020.1806662

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