IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice
The metabolic gene isocitrate dehydrogenase 1 (IDH1) is commonly mutated in lower grade glioma (LGG) and secondary glioblastoma (GBM). Regulatory T cells (Tregs) play a significant role in the suppression of antitumor immunity in human glioma. Given the importance of Tregs in the overall framework o...
Main Authors: | Leland G. Richardson, Linda T. Nieman, Anat O. Stemmer-Rachamimov, Xijin S. Zheng, Khalifa Stafford, Hiroaki Nagashima, Julie J. Miller, Juri Kiyokawa, David T. Ting, Hiroaki Wakimoto, Daniel P. Cahill, Bryan D. Choi, William T. Curry |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2020-01-01
|
Series: | OncoImmunology |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/2162402X.2020.1806662 |
Similar Items
-
Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL
by: Mathieu Simonin, et al.
Published: (2021-05-01) -
Beyond IDH-Mutation: Emerging Molecular Diagnostic and Prognostic Features in Adult Diffuse Gliomas
by: Kanish Mirchia, et al.
Published: (2020-07-01) -
Peripheral Inflammatory Blood Markers in Diagnosis of Glioma and IDH Status
by: Gaurav Sharma, et al.
Published: (2021-01-01) -
Implications of IDH mutations on immunotherapeutic strategies for malignant glioma
by: Choi, B.D, et al.
Published: (2022) -
IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution
by: Erika F. Rodriguez, et al.
Published: (2020-06-01)