A Western diet impairs CNS energy homeostasis and recovery after spinal cord injury: Link to astrocyte metabolism

A Western diet impairs CNS energy homeostasis and recovery after spinal cord injury: Link to astrocyte metabolism

A diet high in fat and sucrose (HFHS), the so-called Western diet promotes metabolic syndrome, a significant co-morbidity for individuals with spinal cord injury (SCI). Here we demonstrate that the spinal cord of mice consuming HFHS expresses reduced insulin-like growth factor 1 (IGF-1) and its rece...

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Bibliographic Details
Main Authors: Ha Neui Kim, Monica R. Langley, Whitney L. Simon, Hyesook Yoon, Laurel Kleppe, Ian R. Lanza, Nathan K. LeBrasseur, Aleksey Matveyenko, Isobel A. Scarisbrick
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Astrogliosis
Myelin
Insulin
Spinal cord injury
Metformin
Western diet
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302096

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http://www.sciencedirect.com/science/article/pii/S0969996120302096

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