Tetrodotoxin, a Candidate Drug for Nav1.1-Induced Mechanical Pain?

Tetrodotoxin (TTX), the mode of action of which has been known since the 1960s, is widely used in pharmacology as a specific inhibitor of voltage-gated sodium channels (Nav channels). This toxin has contributed to the characterization of the allosteric model of the Nav channel, and to discriminating...

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Bibliographic Details
Main Author: César Mattei
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Marine Drugs
Subjects:
Online Access:http://www.mdpi.com/1660-3397/16/2/72