The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

Summary: In an attempt to unravel functionality of the non-canonical PRC1.1 Polycomb complex in human leukemogenesis, we show that USP7 and TRIM27 are integral components of PRC1.1. USP7 interactome analyses show that PRC1.1 is the predominant Polycomb complex co-precipitating with USP7. USP7 inhibi...

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Bibliographic Details
Main Authors: Henny Maat, Tjerk Jan Atsma, Shanna M. Hogeling, Aida Rodríguez López, Jennifer Jaques, Mirjam Olthuis, Marcel P. de Vries, Chantal Gravesteijn, Annet Z. Brouwers-Vos, Nisha van der Meer, Suzan Datema, Jonas Salzbrunn, Gerwin Huls, Roy Baas, Joost H.A. Martens, Vincent van den Boom, Jan Jacob Schuringa
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:iScience
Subjects:
Molecular Biology
Cell Biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422100403X

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