The Role of Necroptosis: Biological Relevance and Its Involvement in Cancer

by Laura Della Torre, Angela Nebbioso, Hendrik G. Stunnenberg, Joost H.A. Martens, Vincenzo Carafa, Lucia Altucci
Published 2021-02-01

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.

by Marco Carretta, Annet Z Brouwers-Vos, Matthieu Bosman, Sarah J Horton, Joost H A Martens, Edo Vellenga, Jan Jacob Schuringa
Published 2017-01-01

CBFβ-SMMHC Affects Genome-wide Polycomb Repressive Complex 1 Activity in Acute Myeloid Leukemia

by Gaëlle Cordonnier, Amit Mandoli, Nicolas Cagnard, Guillaume Hypolite, Ludovic Lhermitte, Els Verhoeyen, Vahid Asnafi, Niall Dillon, Elizabeth Macintyre, Joost H.A. Martens, Jonathan Bond
Published 2020-01-01

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

by Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga, Jan Jacob Schuringa
Published 2019-12-01

The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem ce...

by Esther Tijchon, Guoqiang Yi, Amit Mandoli, Jos G A Smits, Francesco Ferrari, Branco M H Heuts, Falco Wijnen, Bowon Kim, Eva M Janssen-Megens, Jan Jacob Schuringa, Joost H A Martens
Published 2019-01-01

The Tetraspanin CD9 Affords High-Purity Capture of All Murine Hematopoietic Stem Cells

by Göran Karlsson, Emma Rörby, Cristina Pina, Shamit Soneji, Kristian Reckzeh, Kenichi Miharada, Christine Karlsson, Yanping Guo, Cristina Fugazza, Rajeev Gupta, Joost H.A. Martens, Hendrik G. Stunnenberg, Stefan Karlsson, Tariq Enver
Published 2013-08-01

Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis

by Vincent van den Boom, Henny Maat, Marjan Geugien, Aida Rodríguez López, Ana M. Sotoca, Jennifer Jaques, Annet Z. Brouwers-Vos, Fabrizia Fusetti, Richard W.J. Groen, Huipin Yuan, Anton C.M. Martens, Hendrik G. Stunnenberg, Edo Vellenga, Joost H.A. Martens, Jan Jacob Schuringa
Published 2016-01-01

MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML

by Naidu M. Vegi, Josef Klappacher, Franz Oswald, Medhanie A. Mulaw, Amit Mandoli, Verena N. Thiel, Shiva Bamezai, Kristin Feder, Joost H.A. Martens, Vijay P.S. Rawat, Tamoghna Mandal, Leticia Quintanilla-Martinez, Karsten Spiekermann, Wolfgang Hiddemann, Konstanze Döhner, Hartmut Döhner, Hendrik G. Stunnenberg, Michaela Feuring-Buske, Christian Buske
Published 2016-07-01

The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

by Henny Maat, Tjerk Jan Atsma, Shanna M. Hogeling, Aida Rodríguez López, Jennifer Jaques, Mirjam Olthuis, Marcel P. de Vries, Chantal Gravesteijn, Annet Z. Brouwers-Vos, Nisha van der Meer, Suzan Datema, Jonas Salzbrunn, Gerwin Huls, Roy Baas, Joost H.A. Martens, Vincent van den Boom, Jan Jacob Schuringa
Published 2021-05-01

Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells

by Olivier B. Bakker, Aarón D. Ramírez-Sánchez, Zuzanna A. Borek, Niek de Klein, Yang Li, Rutger Modderman, Yvonne Kooy-Winkelaar, Marie K. Johannesen, Filomena Matarese, Joost H. A. Martens, Vinod Kumar, Jeroen van Bergen, Shuo-Wang Qiao, Knut E. A. Lundin, Ludvig M. Sollid, Frits Koning, Cisca Wijmenga, Sebo Withoff, Iris H. Jonkers
Published 2021-04-01

Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils

by Luigi Grassi, Farzin Pourfarzad, Sebastian Ullrich, Angelika Merkel, Felipe Were, Enrique Carrillo-de-Santa-Pau, Guoqiang Yi, Ida H. Hiemstra, Anton T.J. Tool, Erik Mul, Juliane Perner, Eva Janssen-Megens, Kim Berentsen, Hinri Kerstens, Ehsan Habibi, Marta Gut, Marie Laure Yaspo, Matthias Linser, Ernesto Lowy, Avik Datta, Laura Clarke, Paul Flicek, Martin Vingron, Dirk Roos, Timo K. van den Berg, Simon Heath, Daniel Rico, Mattia Frontini, Myrto Kostadima, Ivo Gut, Alfonso Valencia, Willem H. Ouwehand, Hendrik G. Stunnenberg, Joost H.A. Martens, Taco W. Kuijpers
Published 2018-09-01