Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first‐line platinum chemotherapy in high grade serous ovarian cancer

Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first‐line platinum chemotherapy in high grade serous ovarian cancer

Abstract Background In high grade serous ovarian cancer (HGSOC), there is a spectrum of sensitivity to first line platinum‐based chemotherapy. This study molecularly characterizes HGSOC patients from two distinct groups of chemotherapy responders (good vs. poor). Methods Following primary debulking...

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Bibliographic Details
Main Authors: Johanne I. Weberpals, Trevor J. Pugh, Paola Marco‐Casanova, Glenwood D. Goss, Natalie Andrews Wright, Prisni Rath, Jonathon Torchia, Alexander Fortuna, Gemma N. Jones, Martine P. Roudier, Laurence Bernard, Bryan Lo, Dax Torti, Alberto Leon, Kayla Marsh, Darren Hodgson, Marc Duciaume, William J. Howat, Natalia Lukashchuk, Stanley E. Lazic, Doreen Whelan, Harmanjatinder S. Sekhon
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Cancer Medicine
Subjects:
genomic profiling
high grade serous
immune profiling
ovarian carcinoma
platinum resistance
Online Access:https://doi.org/10.1002/cam4.3831

Internet

https://doi.org/10.1002/cam4.3831

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