Cdkn1a deletion or suppression by cyclic stretch enhance the osteogenic potential of bone marrow mesenchymal stem cell-derived cultures

Cdkn1a deletion or suppression by cyclic stretch enhance the osteogenic potential of bone marrow mesenchymal stem cell-derived cultures

CDKN1A/P21 is a potent inhibitor of cell cycle progression and its overexpression is thought to be associated with inhibition of normal bone regenerative osteogenesis during spaceflight. To test whether CDKN1A/P21 regulates osteogenesis in response to mechanical loading we studied cyclic stretch ver...

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Bibliographic Details
Main Authors: Cassandra M. Juran, Justina Zvirblyte, Margareth Cheng-Campbell, Elizabeth A. Blaber, Eduardo A.C. Almeida
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Stem Cell Research
Subjects:
Mechanotransduction
Mesenchymal stem cells
Single cell transcriptomics
CDKN1A/P21
Cyclic stretch loading
Regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121003603

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http://www.sciencedirect.com/science/article/pii/S1873506121003603

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