Overcoming Monocarboxylate Transporter 8 (MCT8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination

Overcoming Monocarboxylate Transporter 8 (MCT8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination

Cell membrane thyroid hormone (TH) transport can be facilitated by the monocarboxylate transporter 8 (MCT8), encoded by the solute carrier family 16 member 2 (SLC16A2) gene. Human mutations of the gene, SLC16A2, result in the X-linked-inherited psychomotor retardation and hypomyelination disorder, A...

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Bibliographic Details
Main Authors: Jae Young Lee, Min Joung Kim, Devy Deliyanti, Michael F. Azari, Fernando Rossello, Adam Costin, Georg Ramm, Edouard G. Stanley, Andrew G. Elefanty, Jennifer L. Wilkinson-Berka, Steven Petratos
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:EBioMedicine
Subjects:
NKX2.1
Human embryonic stem cells
Monocarboxylate transporter 8
Allan-Herndon-Dudley syndrome
Thyroid hormone
Di-iodothyropropionic acid (DITPA)
Oligodendrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417304140

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http://www.sciencedirect.com/science/article/pii/S2352396417304140

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