De novo actin polymerization is required for model Hirano body formation in Dictyostelium

De novo actin polymerization is required for model Hirano body formation in Dictyostelium

Hirano bodies are eosinophilic, actin-rich inclusions found in autopsied brains in numerous neurodegenerative diseases. The mechanism of Hirano body formation is unknown. Mass spectrometry analysis was performed to identify proteins from partially purified model Hirano bodies from Dictyostelium. Thi...

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Bibliographic Details
Main Authors: Yun Dong, Sonbol Shahid-Salles, Dan Sherling, Nathan Fechheimer, Nathan Iyer, Lance Wells, Marcus Fechheimer, Ruth Furukawa
Format: Article
Language:English
Published: The Company of Biologists 2016-06-01
Series:Biology Open
Subjects:
Dictyostelium
Hirano body
Actin binding protein
Mass spectrometry
Arp2/3
Profilin
WASH
HSPC300
Online Access:http://bio.biologists.org/content/5/6/807

Internet

http://bio.biologists.org/content/5/6/807

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