SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn’s Disease and Peripheral T Cell Reduction

SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn’s Disease and Peripheral T Cell Reduction

In our previous study, we observed a severe reduction in the Src homology 2-containing-inositol-phosphatase-1 (SHIP1) protein in a subpopulation of subjects from a small adult Crohn’s Disease (CD) cohort. This pilot study had been undertaken since we had previously demonstrated that engineered defic...

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Bibliographic Details
Main Authors: Sandra Fernandes, Neetu Srivastava, Raki Sudan, Frank A. Middleton, Amandeep K. Shergill, James C. Ryan, William G. Kerr
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
SHIP1
Crohn’s disease
T cells
human inflammatory bowel disease
INPP5D
ATG16L1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01100/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01100/full

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